Chinese scientists have become the first in the world to successfully perform high-resolution, multicolour deep-brain imaging in freely moving mice. The breakthrough was achieved using a newly developed, ultra-light miniature two-photon microscope and is set to significantly advance neuroscience research.
According to
Xinhua News Agency, a partner of TV BRICS, the study offers a new approach to observing the intricate activity of neurons and synapses in real time, addressing a long-standing challenge in brain science.
The breakthrough was led by Professor Cheng Heping at Peking University, building on earlier work from 2017. A key innovation was the development of a new ultra-broadband hollow-core fibre, created in collaboration with Beijing Information Science and Technology University. Unlike previous versions, this fibre transmits ultrafast laser pulses across multiple wavelengths, enabling multicolour imaging for the first time.
Weighing only 2.6 grams, the microscope was mounted on mice with Alzheimer’s disease. It simultaneously captured red, green, and blue signals representing neuronal activity, mitochondrial function, and plaque deposits. The team observed early abnormalities near plaques, offering fresh insight into the disease’s progression.
Professor Cheng said the innovation opens new possibilities for studying brain networks, disease mechanisms, drug testing, and brain-computer interface development.
Photo: magicmine /
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